Dele Alli returns and Danny Rose keeps his place as Tottenham make three changes to face Manchester City.
Alli, who was dropped to the bench for the midweek win over Brighton, replaces Erik Lamela.
Rose starts his second successive Premier League game at left-back since returning from a long-term injury and Kieran Tripper comes in for Serge Aurier at right-back.
Mousa Dembele starts in midfield instead of Moussa Sissoko.
Kyle Walker returns against the club that sold him for £50m in the summer as one of three changes for City, as David Silva misses out on the matchday squad altogether.
Man City:Ederson; Walker, Mangala, Otamendi, Delph; Fernandinho, Gundogan, Dw Bruyne, Sterling, Sane; Aguero
Subs: Bravo, Danilo, B. Silva, Jesus, Zinchenko, Toure, Foden
Tottenham: Lloris, Trippier, Dier, Vertonghen, Rose, Winks, Dembele, Alli, Eriksen, Son, Kane.
Subs: Vorm, Davies, Foyth, Aurier, Sissoko, Lamela, Llorente.