Brentford will be without midfielder Romaine Sawyers through suspension, but head coach Dean Smith has no fresh injury concerns from players returning after international duty.
Andreas Bjelland has stepped up his recovery from a calf problem but is not expected back in contention until Easter Monday at the earliest.
Sheffield United expect to have both Welsh duo Lee Evans and David Brooks available following international duty.
Chris Basham will again be in the squad after missing the draw against Nottingham Forest following the birth of his child.
Last season
No corresponding fixture
Last five league matches
Brentford L W L L D; Sheff Utd W L D W D
Top scorers (all competitions)
Ollie Watkins (Brentford) 10; Leon Clarke (Sheff Utd) 15
Match odds
Brentford: 21-20
Sheffield United: 12-5
Draw: 13-5
Referee: Jeremy Simpson (Lancashire)